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Science. 1983 Mar 4;219(4588):1085-7.

Discrete visual defects in pearl mutant mice.

Abstract

The mutant mouse pearl, characterized by its hypopigmentation, has a specific functional defect in a sensory system--the retina. The intact pearl mouse has reduced sensitivity in the dark-adapted condition. Normal sensitivity is restored by isolation and superfusion of the retina with bicarbonate-buffered Ringer solution, suggesting that the retinal expression of the pearl mutation depends on a diffusible substance. The pearl phenotype is described as a possible model for human congenital stationary night blindness.

PMID:
6600521
DOI:
10.1126/science.6600521
[Indexed for MEDLINE]

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