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16,16-Dimethyl prostaglandin E2 stimulates growth and maturation of rat gastric and small-intestinal mucosa.


In adult rats topical application of 16,16-dm PGE2 (PGE) every 8 h for three weeks led to a dose-dependent increase of the height of the gastric and duodenal mucosa, especially pronounced in the antrum (+115% with the high dose). In the gastric corpus this resulted from an enlargement of the lamina propria and the epithelial cell mass, the latter mainly from a hyperplasia of the surface and foveolar mucous cells. In contrast, the number of parietal cells was not affected. These findings were corroborated by the observation that an increase of antral mucosal height was also induced by a similar parenteral PGE treatment regimen (dosage 25 micrograms/kg). Both longterm intragastric and intraperitoneal PGE treatment led to an increase in DNA synthesis within the mucosa of the gastric antrum and corpus by 19 to 74%. In a third study 25 or 100 micrograms/kg of PGE applied every 8 h intragastrically to 10 suckling rats from the 7th to 11th postnatal day resulted in a dose-dependent increase in the length of the villi and the disaccharidase activities (30-630%). These studies suggest that 16,16-dm PGE2 exhibits a trophic effect on both the stomach and the small bowel.

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