Specific inhibition of human leukocyte elastase by substituted alpha-pyrones

Experientia. 1984 Apr 15;40(4):361-2. doi: 10.1007/BF01952552.

Abstract

Several a-pyrones have been synthesized and investigated for their in vitro inhibitory activity using a-chymotrypsin (a-CT), porcine pancreatic elastase (PPE) and human leukocyte elastase (HLE). 4-Hydroxy-6-undecyl-2H-pyran-2-one 4, 4-Hydroxy-6-[(1-butyl)heptyl]-2H-pyran-2-one 5 and 4-Methoxy-6-[(1-butyl) heptyl]-2H-pyran-2-one 6 were found to be specific inhibitors of HLE. These compounds constitute a promising new class of HLE inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Chymotrypsin / antagonists & inhibitors
  • Humans
  • Leukocytes / enzymology*
  • Pancreatic Elastase / antagonists & inhibitors*
  • Pyrans / pharmacology*
  • Pyrones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Pyrans
  • Pyrones
  • Chymotrypsin
  • Pancreatic Elastase