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Cancer Treat Rep. 1984 Jul-Aug;68(7-8):1039-41.

Sequential continuous infusion with doxorubicin and vinblastine: an effective chemotherapy combination for patients with advanced breast cancer previously treated with cyclophosphamide, methotrexate, 5-FU, vincristine, and prednisone.


Forty-two patients with metastatic breast carcinoma previously treated with a combination of cyclophosphamide, methotrexate, and 5-FU, with or without vincristine or prednisone, were treated at relapse with a sequential combination of doxorubicin and vinblastine given by continuous infusion. Two patients achieved complete remission and 16 achieved partial remission for a total response rate of 43%. The median time to progression for responders and patients with stable disease was 10 and 4 months, respectively. Neutropenia was the major toxic effect but did not lead to any fatality.

[Indexed for MEDLINE]

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