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Farmaco Sci. 1984 Jan;39(1):16-22.

Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.


A number of N-substituted 4-hydroxy-, 4-acyloxy- and 4-alkoxy-2-pyrrolidinones were examined by a screening method predictive of their activity on cognitive processes. The 1-aminocarbonylmethyl-substituted compounds showed a favorable effect on learning and memory, and among them the most active was the 4-hydroxy derivative, oxiracetam, which had a potency considerably higher than piracetam, used for comparison purposes.

[Indexed for MEDLINE]

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