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J Pharm Sci. 1984 Sep;73(9):1309-11.

Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats.

Abstract

Polymethyl [1-14C]methacrylate nanoparticles were administered orally to bile cannulated rats. Ten to fifteen percent of the administered radioactivity was absorbed and found in the bile and urine. Within 48 h, 94-97% of the absorbed radioactivity had been eliminated from the body. After 8 d, the highest residual radioactivity was found in the bone marrow, fatty renal tissue, stomach, liver, and lymph nodes.

PMID:
6491960
DOI:
10.1002/jps.2600730934
[Indexed for MEDLINE]

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