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J Allergy Clin Immunol. 1984 Oct;74(4 Pt 2):567-72.

Risk factors for drug allergy.

Abstract

Judging from available data on penicillin allergy there appear to be multiple definable risk factors for drug-induced immunopathology. The induction of a drug-specific immune response can be influenced by the age of the patient; underlying genetic or metabolic factors, which may restrict ability to initiate a drug-specific immune response; the chemical properties of the drug, largely its protein reactivity; and the dose and duration of treatment as well as the route of drug administration. The elicitation of drug-induced immunopathology is a function of the persistence of a drug-specific immune response; the frequency of drug treatment and its dose and duration; and probable constitutional factors that may determine in an important way the efficiency with which a drug-specific immune response can be translated into a systemic allergic reaction.

PMID:
6491103
DOI:
10.1016/0091-6749(84)90108-8
[Indexed for MEDLINE]

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