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Biochem Biophys Res Commun. 1984 Sep 17;123(2):691-6.

In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction.

Abstract

The in vitro biosynthesis of isoprene from DL-mevalonate in the cytosolic fraction of rat liver is described. Evidence is provided suggesting a non-enzymatic formation of isoprene from isopentenyl pyrophosphate and/or dimethylallyl pyrophosphate. Furthermore, the data establish an alternate fate of the mevalonate carbon skeleton providing the first evidence that breath isoprene is linked to cholesterol biosynthesis.

PMID:
6487307
DOI:
10.1016/0006-291x(84)90284-5
[Indexed for MEDLINE]

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