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Klin Wochenschr. 1984;62 Suppl 2:105-8.

Influence of nicotine on N-nitrosomethylurea-induced mammary tumors in rats.

Abstract

The possible influence of nicotine tartrate on carcinogenesis induced by N-Nitrosomethylurea (NMU) in the mammary gland of female Sprague-Dawley rats was investigated. NMU given i.v. at a single dose of 50 mg/kg on day 52 induced a 100% yield of mammary tumors. Additional subcutaneous administration of individual doses of 0.5 mg/kg of nicotine on days 46-52 and 55-145 (twice a week), respectively, did not modify the NMU-induced carcinogenesis. No further tumors developed in untreated and nicotine-treated animals, thus giving no evidence that nicotine can influence chemical-induced tumors.

PMID:
6482321
[Indexed for MEDLINE]

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