Send to

Choose Destination
See comment in PubMed Commons below
Transplantation. 1984 Sep;38(3):280-4.

Determinants of immunological responsiveness in recurrent spontaneous abortion.


A defined group of 20 women suffering recurrent spontaneous abortions of unknown etiology was studied for determinants relevant to immune responsiveness. A low prevalence of serum anti-CMV antibodies (35%; cf, 65% in controls)--but not anti-herpes-simplex-virus or Epstein-Barr virus antibodies--was noted. Only two (10%) of these women had lymphocytotoxic antibodies following their repeated pregnancies; low titer anti-sperm antibody was present in two other of these women. Whereas there was no significantly increased sharing of HLA-A or -B antigens within these couples compared with controls, there was an increased incidence of apparent HLA-B antigen homozygosity in the women. These data indicate a degree of immunological nonresponsiveness both to cytomegalovirus and to cell-surface alloantigens in habitually aborting women and, together with MLC data, provide further evidence that immunogenetic events may be relevant to reproductive success.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center