Send to

Choose Destination
See comment in PubMed Commons below
Int J Biochem. 1984;16(6):623-8.

Intracellular localization and characterization of 3-hydroxykynureninase in human liver.


3-hydroxykynureninase in human liver was present in cytosol and mitochondria. The cytosolic enzyme and mitochondrial enzyme had the same physiological and enzymic properties. The enzyme had a mol. wt of 130,000 by gel filtration and isoelectric point of pH 5.9. The enzyme was active for 3-hydroxykynurenine and kynurenine, and its activity ratio was 15:1. The apparent Km values of the enzyme were 7.7 X 10(-5) M for 3-hydroxykynurenine, 1.0 X 10(-3) M for kynurenine and 2.5 X 10(-6) M for pyridoxal 5'-phosphate with 3-hydroxykynurenine. Some other properties of purified enzymes are described.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center