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Arq Neuropsiquiatr. 1984 Jun;42(2):126-31.

Demonstration of antibody and cellular immune response to brain extract in West and Lennox-Gastaut syndromes.


We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of this autoimmune response in the pathogenesis of West and Lennox-Gastaut syndromes remains to the elucidated.

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