Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Med Genet. 1984 Jun;18(2):357-64.

A possible explanation for the low incidence of gonosomal aneuploidy among the offspring of triplo-X individuals.

Abstract

A review of the reproductive performance of 47,XXX individuals showed that the incidence of gonosomal aneuploidy among the offspring is low. To explain this unexpected phenomenon it is hypothesized that fertile triplo-X individuals have chromosomally normal oogonia due to mitotic nondisjunction in a cell from which the primordial germ line took origin. Mosaic 46,XX/47,XXX individuals have a somewhat higher risk of bearing aneuploid offspring, possibly due to a constitutional tendency toward gonosomal nondisjunction.

PMID:
6465205
DOI:
10.1002/ajmg.1320180220
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center