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Nature. 1981 Nov 19;294(5838):217-23.

lambda Repressor and cro--components of an efficient molecular switch.

Abstract

In a lysogen, most genes of phage lambda are repressed; in response to a transient induction signal, they are efficiently switched on. The switch, which consists in part of a tripartite operator to which two regulatory proteins bind, depends not only on DNA--protein interactions, but also on effects transmitted from one DNA-bound protein to another. lambda Exemplifies a strategy that facilitates efficient switching between two physiological states in response to a transient signal.

PMID:
6457992
DOI:
10.1038/294217a0
[Indexed for MEDLINE]

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