Format

Send to

Choose Destination
Brain Res. 1981 Nov 23;225(1):1-21.

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.

Abstract

The developmental morphology of visual cortical neurons (their numbers, dendritic arborization and numbers of spines) in 14 fetuses and infants with Down's syndrome were studied and compared with that of neurologically normal, age-matched controls. Fetuses with Trisomy 21 showed the same neuronal morphology and spine counts as control fetuses. However, the newborns and older infants with Down's syndrome showed shorter basilar dendrites and decreased numbers of spines with altered morphology and defective cortical layering.

PMID:
6457667
DOI:
10.1016/0006-8993(81)90314-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center