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J Affect Disord. 1980 Jun;2(2):89-94.

A re-examination of the clinical effects of imipramine and amitriptyline in depressive illness.

Abstract

A double-blind trial of amitriptyline and imipramine was conducted in patients suffering from depressive illness. The results failed to confirm the prevalent belief that amitriptyline has a greater sedative effect and superior anxiolytic properties than imipramine. The therapeutic effect of these drugs was not shown to be related to their sedative properties and with regard to anxiety the reverse appeared to be true.

PMID:
6448887
DOI:
10.1016/0165-0327(80)90008-7
[Indexed for MEDLINE]

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