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NIDA Res Monogr. 1984;55:159-63.

Double-blind comparison of desipramine and placebo in withdrawal from cocaine dependence.


Desipramine was compared with a placebo under double-blind conditions to determine if it is effective treatment for withdrawal from cocaine dependence. Eleven (11) subjects received desipramine and 11 received placebo. There was no significant statistical difference between groups in self-report on effectiveness; retention in treatment; cessation of cocaine use; or suppression of withdrawal scores. Although desipramine appears to be no more effective than placebo in withdrawal from cocaine use or suppression of withdrawal scores, it may be useful in the long-term treatment of this condition.

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