Abstract
In the presence of various liver S9 preparations induced by different polycyclic aromatic hydrocarbons, the weak carcinogen, benz[a]anthracene, exhibited mutagenic activities comparable to those of benzo[a]pyrene in the Ames test. A series of positive correlations were found between mutagenic activity and the hydroxylation products of benz[a]anthracene at the 3,4-, 5,6- and 8,9-positions, of which 5,6-position was the most pronounced one (p less than 0.01). Our results suggest that the observed mutagenic activity is due mainly to the generation of K-region epoxides.
MeSH terms
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Animals
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Benz(a)Anthracenes / toxicity*
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Environmental Pollutants / toxicity*
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Enzyme Induction
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Kinetics
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Male
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Mice
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Mice, Inbred Strains
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology*
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Mixed Function Oxygenases / biosynthesis*
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Mutagenicity Tests
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Mutagens*
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Mutation*
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Polychlorinated Biphenyls / toxicity*
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Polycyclic Compounds / toxicity*
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Rats
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Rats, Inbred Strains
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Salmonella typhimurium / drug effects
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Structure-Activity Relationship
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Time Factors
Substances
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Benz(a)Anthracenes
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Environmental Pollutants
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Mutagens
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Polycyclic Compounds
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clophen A50
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benz(a)anthracene
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Polychlorinated Biphenyls
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Mixed Function Oxygenases