New approach to the localisation of phaeochromocytoma: imaging with iodine-131-meta-iodobenzylguanidine

Br Med J (Clin Res Ed). 1984 May 26;288(6430):1587-91. doi: 10.1136/bmj.288.6430.1587.

Abstract

Thirty eight patients with known or suspected phaeochromocytoma were studied by radioisotope imaging after intravenous administration of iodine-131-meta- iodobenzylguanidine (131I- mIBG ), a radiopharmaceutical which has affinity for chromaffin tumours. Seventeen positive results (including one false positive) and 21 negative results (including two false negatives) were obtained. Clinical accuracy was 92%. Urinary noradrenaline concentrations were raised in all patients with confirmed phaeochromocytoma. These findings show that 131I- mIBG is of value in localising and assessing the extent of chromaffin tumours.

MeSH terms

  • 3-Iodobenzylguanidine
  • Adolescent
  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / urine
  • Adult
  • Aged
  • Dopamine / urine
  • Epinephrine / urine
  • Female
  • Humans
  • Iodine Radioisotopes
  • Iodobenzenes*
  • Male
  • Middle Aged
  • Norepinephrine / urine
  • Pheochromocytoma / diagnostic imaging*
  • Pheochromocytoma / secondary
  • Pheochromocytoma / urine
  • Radionuclide Imaging
  • Tissue Distribution

Substances

  • Iodine Radioisotopes
  • Iodobenzenes
  • 3-Iodobenzylguanidine
  • Dopamine
  • Norepinephrine
  • Epinephrine