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Nature. 1984 Feb 2-8;307(5950):417-22.

The molecular biology of immunoglobulin D.

Abstract

Immunoglobulin D (IgD) is co-expressed with immunoglobulin M (IgM) on the membranes of most B cells, yet its biological function has remained a mystery. Recent detailed information on the structure and transcription of the unusual IgD heavy chain (delta) gene in mouse suggests a complex genetic control. A model is presented for the developmental regulation of IgM and IgD and roles suggested for the membrane and secreted forms of IgD in the immune network.

PMID:
6420708
DOI:
10.1038/307417a0
[Indexed for MEDLINE]

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