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Nature. 1983 Nov 24-30;306(5941):387-9.

Immunoglobulin heavy chain binding protein.

Abstract

Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.

PMID:
6417546
DOI:
10.1038/306387a0
[Indexed for MEDLINE]

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