GnRH and TRH stimulation were performed on 4 patients affected by 21-beta-hydroxylase adrenal deficit. Plasmatic FSH, LH, 17-beta-estradiol, HPRL were assayed before and after GnRH, and HPRL before and after TRH. The results seem to prove that these tests are useless for the diagnosis of adrenal enzymatic deficit. On the other hand, they provide interesting additional information on physiopathological relations between adrenals and gonadotropins and between HPRL and adrenals.