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Cell Immunol. 1983 Sep;80(2):392-404.

Changes in cell populations and immunoglobulin-producing cells in the spleens of mice infected with Trypanosoma cruzi: correlations with parasite-specific antibody response.


Infection of mice with Trypanosoma cruzi elicits the production of parasite-specific antibodies which reach high levels and remain elevated for at least 105 days of infection. The more susceptible C3H(He) mouse actually has a higher level of "natural" antibodies for T. cruzi but may show a greater lag time in the production of antibodies in response to infection than the more resistant C57BL/6 mouse. Comparison of the kinetics of antibody production against T. cruzi and the numbers of immunoglobulin-producing cells in the spleen during the course of infection suggests that a large number of the immunoglobulin-producing cells are probably producing antibodies directed against the parasite and are not the result of an exhaustive polyclonal B-cell activation. Cell numbers in the spleen change dramatically both in total numbers and in the percentage of different cell types during infection with T. cruzi. The percentage of T cells in the spleen remains relatively unchanged throughout infection in both mouse strains tested but numbers of Ig-positive cells decrease markedly during the acute phase of infection while macrophage numbers increase up to sixfold. Cell numbers and proportions of B cells, T cells, and macrophages return to near normal values by 105 days of infection in the C57BL/6 mouse.

[Indexed for MEDLINE]

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