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Br Med J (Clin Res Ed). 1983 Apr 30;286(6375):1381-3.

Sweat tests to diagnose cystic fibrosis in adults.

Abstract

Twenty five patients with cystic fibrosis and 25 controls were studied to define a sweat sodium concentration in adults that could be taken as diagnostic of cystic fibrosis. Some of the controls had a sweat sodium concentration of over 50 mmol(mEq)/l, and thus cystic fibrosis should be diagnosed in an adult only when two measurements of sweat sodium concentration are above 70 mmol/l. In cases in which the sweat sodium concentration was borderline a suppression test using fludrocortisone improved the accuracy of diagnosis; this test entails recording the lowest concentration reached after administration of the drug. A scatter diagram of the baseline sweat sodium concentrations plotted against the lowest concentration attained after suppression with fludrocortisone may aid the diagnosis further.

PMID:
6404469
PMCID:
PMC1547859
DOI:
10.1136/bmj.286.6375.1381
[Indexed for MEDLINE]
Free PMC Article

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