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Cancer Drug Deliv. 1984 Summer;1(3):199-205.

Altered tissue distribution of amphotericin B by liposomal encapsulation: comparison of normal mice to mice infected with Candida albicans.

Abstract

Recently, it has been observed that encapsulation of Amphotericin B (Amp-B) into multilamellar vesicles (liposomes) decreases the toxicity associated with the administration of Amp-B, while maintaining its antifungal efficacy. In this study, the tissue concentrations of Amp-B in normal mice and in mice infected with Candida albicans were examined. Amp-B concentrations in various tissues were quantitated by high-performance liquid chromatography. Liposomal encapsulation improved the delivery of Amp-B to the liver, spleen, lung, and kidney in both normal and infected mice. Furthermore, after injection of the encapsulated drug, Amp-B was demonstrable in brain tissue of infected animals at potentially therapeutic concentrations. None was demonstrable in the brains of normal animals or animals injected with free Amp-B. The results suggest that capillary endothelial damage and phagocytic cell uptake may contribute to an enhanced liposome delivery of Amp-B to those organs most frequently infected with fungi.

PMID:
6399857
DOI:
10.1089/cdd.1984.1.199
[Indexed for MEDLINE]

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