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Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9.

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Abstract

Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.

PMID:
6392892
DOI:
10.1038/312724a0
[Indexed for MEDLINE]

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