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Frequent isolation of Propionibacterium acnes from sarcoidosis lymph nodes.

Abstract

Isolation of Propionibacterium acnes from biopsied lymph nodes of sarcoidosis patients and from the lymph nodes or other tissues of non-sarcoidosis patients was carried out, carefully avoiding contamination by skin-resident P. acnes. Out of 40 sarcoidosis lymph nodes examined, 31 nodes (77.5%) showed a positive culture of P. acnes, while 38 of 180 (21.1%) non-sarcoidosis tissues revealed positive results, the difference being significant (p less than 0.001). Among non-sarcoidosis tissues, the intra-thoracic lymph nodes demonstrated a positive culture in low percentages, while intra-abdominal lymph nodes indicated no positive culture. The possible role of this microorganism in the etiology of sarcoidosis is discussed.

PMID:
6377763
[Indexed for MEDLINE]

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