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Nature. 1984 Jan 19-25;307(5948):241-5.

Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

Abstract

The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.

PMID:
6363938
DOI:
10.1038/307241a0
[Indexed for MEDLINE]

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