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Am J Trop Med Hyg. 1983 Jul;32(4):682-4.

In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line.

Abstract

When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.

PMID:
6349397
[PubMed - indexed for MEDLINE]
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