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J Med Chem. 1983 Aug;26(8):1196-200.

Inhibitors of glycolic acid oxidase. 4-substituted 2,4-dioxobutanoic acid derivatives.

Abstract

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized. These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase. The I50 value of the two most potent representatives, 4-(4'-bromo[1,1'-biphenyl]-4-yl)-2, 4-dioxobutanoic acid (8) and 4-[4'-[[(3,4-dihydro-3-hydroxy-2H-1, 5-benzodioxepin-3-yl)methyl]thio][1,1'-biphenyl]-4-yl]-2, 4-dioxobutanoic acid (13) is 6 X 10(-8)M.

PMID:
6348285
DOI:
10.1021/jm00362a020
[Indexed for MEDLINE]

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