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Nature. 1978 Mar 23;272(5651):329-33.

Brain histamine receptors as targets for antidepressant drugs.

Abstract

A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.

PMID:
634355
DOI:
10.1038/272329a0
[Indexed for MEDLINE]

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