[Metabolism of exogenous steroids in adrenal cortex rat cells in culture: establishment of hydroxylation in position 11-beta or 18]

C R Seances Soc Biol Fil. 1984;178(1):77-83.
[Article in French]

Abstract

Newborn rat adrenocortical cells in primary culture have allowed us to establish the place of 11 beta/18-hydroxylation in the biosynthesis and metabolism of corticosteroid hormones. The affinity of the 11 beta/18-hydroxylation system has been determined with respect to known or potential intermediates. It has equally been examined in relation to 2 alpha-, 6 alpha-, 6 beta-, 16 alpha or 17 alpha-hydroxyprogesterone and 6 alpha-, 6 beta- or 17 alpha-hydroxy-11-deoxycorticosterone.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex / drug effects
  • Adrenal Cortex / metabolism*
  • Adrenal Cortex Hormones / metabolism*
  • Adrenocorticotropic Hormone / pharmacology
  • Animals
  • Animals, Newborn
  • Cells, Cultured
  • Cytochrome P-450 CYP11B2
  • Hydroxylation
  • Rats
  • Steroid 11-beta-Hydroxylase / metabolism*
  • Steroid Hydroxylases / metabolism*

Substances

  • Adrenal Cortex Hormones
  • Adrenocorticotropic Hormone
  • Steroid Hydroxylases
  • Cytochrome P-450 CYP11B2
  • Steroid 11-beta-Hydroxylase