Abstract
Newborn rat adrenocortical cells in primary culture have allowed us to establish the place of 11 beta/18-hydroxylation in the biosynthesis and metabolism of corticosteroid hormones. The affinity of the 11 beta/18-hydroxylation system has been determined with respect to known or potential intermediates. It has equally been examined in relation to 2 alpha-, 6 alpha-, 6 beta-, 16 alpha or 17 alpha-hydroxyprogesterone and 6 alpha-, 6 beta- or 17 alpha-hydroxy-11-deoxycorticosterone.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Cortex / drug effects
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Adrenal Cortex / metabolism*
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Adrenal Cortex Hormones / metabolism*
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Adrenocorticotropic Hormone / pharmacology
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Animals
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Animals, Newborn
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Cells, Cultured
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Cytochrome P-450 CYP11B2
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Hydroxylation
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Rats
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Steroid 11-beta-Hydroxylase / metabolism*
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Steroid Hydroxylases / metabolism*
Substances
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Adrenal Cortex Hormones
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Adrenocorticotropic Hormone
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Steroid Hydroxylases
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Cytochrome P-450 CYP11B2
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Steroid 11-beta-Hydroxylase