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J Med Chem. 1984 Jul;27(7):894-900.

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

Abstract

A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.

PMID:
6330360
DOI:
10.1021/jm00373a015
[Indexed for MEDLINE]

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