Evidence for high affinity [3H] imipramine binding sites in human lung

Biochem Biophys Res Commun. 1984 May 16;120(3):926-32. doi: 10.1016/s0006-291x(84)80195-3.

Abstract

[3H] imipramine exhibits both saturable and high affinity binding sites in human lung with a maximal number of binding sites of 7.50 pmoles/mg protein and a dissociation constant of 1.74 nM. Displacement studies indicate that these sites can be considered as specific of imipramine, tricyclic compounds and also monoamine uptake inhibitors:fluoxetine and nisoxetine. Atypical antidepressants were inactive as ligands of main known receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents / pharmacology
  • Antidepressive Agents, Tricyclic / pharmacology
  • Binding, Competitive
  • Carrier Proteins*
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Lung / metabolism*
  • Receptors, Drug*
  • Receptors, Neurotransmitter / metabolism*

Substances

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Carrier Proteins
  • Receptors, Drug
  • Receptors, Neurotransmitter
  • imipramine receptor