Abstract
[3H] imipramine exhibits both saturable and high affinity binding sites in human lung with a maximal number of binding sites of 7.50 pmoles/mg protein and a dissociation constant of 1.74 nM. Displacement studies indicate that these sites can be considered as specific of imipramine, tricyclic compounds and also monoamine uptake inhibitors:fluoxetine and nisoxetine. Atypical antidepressants were inactive as ligands of main known receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antidepressive Agents / pharmacology
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Antidepressive Agents, Tricyclic / pharmacology
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Binding, Competitive
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Carrier Proteins*
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Humans
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In Vitro Techniques
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Kinetics
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Lung / metabolism*
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Receptors, Drug*
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Receptors, Neurotransmitter / metabolism*
Substances
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Antidepressive Agents
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Antidepressive Agents, Tricyclic
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Carrier Proteins
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Receptors, Drug
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Receptors, Neurotransmitter
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imipramine receptor