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Annu Rev Med. 1984;35:469-79.

Viral infections predisposing to bacterial infections.


Epidemiological and experimental evidence support the hypothesis that primary viral infection increases host susceptibility to secondary microbial invasion. The evidence is most compelling for a correlation between upper respiratory tract viruses and bacterial sinopulmonary disease; and cytomegalovirus and opportunistic fungal, bacterial and protozoal pathogens invading multiple sites. While a number of virus-induced alterations in host defenses have been described, the determinants of virus pathogenicity are still poorly understood.

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