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Neurotoxicology. 1984 Spring;5(1):113-7.

Manganese ions, oxidation reactions and the superoxide radical.

Abstract

The variable valency of the transition element manganese allows it to catalyse redox reactions. This can be made use of in mangano -superoxide dismutase enzymes, but manganese-induced oxidation of NADH and dihydroxyflumarates generate damaging oxygen radicals. Manganese-stimulated oxidations of adrenalin and its derivatives to form toxic products may be involved in the etiology of manganese neurotoxicity.

PMID:
6326006
[Indexed for MEDLINE]
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