Abstract
A total of 5724 base pairs of a recombinant phage DNA containing a human HLA-DR heavy chain gene including flanking regions has been analyzed. The regions corresponding to all the exons have been identified. The sites of initiation of transcription and polyadenylation have been determined. A large intron of 2399 base pairs separates the first exon containing the 5' untranslated region and the signal peptide from the second exon containing the N-terminal peptide domain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bacteriophage lambda / genetics
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Base Composition
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Base Sequence
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Cloning, Molecular
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DNA Restriction Enzymes
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DNA, Recombinant
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Female
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Fetus
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Genes*
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HLA-DR Antigens
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Histocompatibility Antigens Class II / genetics*
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Humans
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Liver / immunology
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Major Histocompatibility Complex*
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Molecular Weight
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Pregnancy
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Transcription, Genetic*
Substances
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DNA, Recombinant
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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DNA Restriction Enzymes