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Mol Gen Genet. 1984;193(3):554-6.

Tn4001: a gentamicin and kanamycin resistance transposon in Staphylococcus aureus.

Abstract

We describe a 4.5 kilobase transposon, Tn4001, which mediates resistance to gentamicin, tobramycin and kanamycin in Staphylococcus aureus. Originally detected in plasmid pSK1, Tn4001 was shown to undergo rec-independent transposition to the chromosome from this plasmid and from an inserted derivative of the plasmid pII147. Heteroduplexes between plasmids with and without Tn4001 demonstrated a characteristic stem and loop structure with inverted repeats of approx. 1.3 kilobases.

PMID:
6323927
DOI:
10.1007/bf00382099
[Indexed for MEDLINE]

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