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Med Hypotheses. 1983 Nov;12(3):253-68.

The Na,K-ATPase hypothesis for manic-depression. I. General considerations.

Abstract

An hypothesis is presented to explain and integrate experimental and clinical observations on manic-depressive (bipolar or biphasic) psychosis. The model is based on alterations in the activity of the sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) pump. A reduction in the activity of the Na,K-ATPase can be responsible for both phases of the disorder.

PMID:
6321918
DOI:
10.1016/0306-9877(83)90042-7
[Indexed for MEDLINE]

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