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Proc Natl Acad Sci U S A. 1984 Jan;81(1):155-9.

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.

Abstract

Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.

PMID:
6320162
PMCID:
PMC344629
DOI:
10.1073/pnas.81.1.155
[Indexed for MEDLINE]
Free PMC Article

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