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Nature. 1983 Dec 22-1984 Jan 4;306(5945):756-60.

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse.


A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.

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