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Nature. 1983 Aug 18-24;304(5927):602-6.

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

PMID:
6308473
DOI:
10.1038/304602a0
[Indexed for MEDLINE]

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