Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes

N Engl J Med. 1983 Jan 27;308(4):199-202. doi: 10.1056/NEJM198301273080406.
No abstract available

MeSH terms

  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / genetics*
  • Cell Line
  • DNA, Neoplasm / genetics
  • Drug Resistance
  • Gene Amplification
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Methotrexate / therapeutic use*
  • Mutation

Substances

  • DNA, Neoplasm
  • Methotrexate