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Kidney Int. 1982 Jun;21(6):877-9.

Choline kinase activity along the rabbit nephron.


Choline kinase catalyzes the phosphorylation of choline to phosphorylcholine which is thus made available for phosphatidylcholine biosynthesis. Choline kinase activity was determined in defined microdissected structures of rabbit nephron with a radiochemical microprocedure. Enzyme activity was present in all segments tested. When referred to tubular length, the highest activities were found in proximal convoluted tubules. Due to the lower protein content of distal structures these segments exhibited higher enzyme activities when referred to micrograms of protein. From this distribution pattern it was concluded that all nephron segments are able to use extracellular choline for phosphatidylcholine biosynthesis.

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