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Science. 1982 Oct 22;218(4570):381-4.

Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli.


The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid enabled synthesis in Escherichia coli of an immunoreactive gD-related polypeptide. The potential of this system for preparation of a type-common herpes simplex virus vaccine is discussed.

[Indexed for MEDLINE]

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