Abstract
N-Acetylmannosamine did not support the growth of Candida albicans, and this sugar was not accumulated by cells. Incubation of starved yeast cells at 37 degrees C with N-acetylmannosamine plus glucose resulted in germ tube formation. Furthermore, N-acetylmannosamine alone induced the uptake system for N-acetylglucosamine and the enzymes of the N-acetylglucosamine catabolic pathway to the same extent as the natural substrate. Induction of the uptake system and the enzymes was observed at 28 degrees C without germ tube formation and at 37 degrees C with germ tube formation. N-Acetylmannosamine is thus a gratuitous inducer for enzymes of the N-acetylglucosamine pathway and germ tube formation in C. albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylglucosamine / metabolism*
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Aldose-Ketose Isomerases*
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Amidohydrolases / biosynthesis
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Candida albicans / cytology
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Candida albicans / enzymology
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Candida albicans / physiology*
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Carbohydrate Epimerases / biosynthesis
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Enzyme Induction
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Glucosamine / analogs & derivatives*
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Hexosamines / pharmacology*
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Phosphotransferases (Alcohol Group Acceptor)*
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Phosphotransferases / biosynthesis
Substances
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Hexosamines
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Phosphotransferases
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Phosphotransferases (Alcohol Group Acceptor)
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N-acetylglucosamine kinase
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Amidohydrolases
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N-acetylglucosamine-6-phosphate deacetylase
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glucosamine-6-phosphate isomerase
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Carbohydrate Epimerases
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Aldose-Ketose Isomerases
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Glucosamine
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Acetylglucosamine
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N-acetylmannosamine