Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence

Am J Trop Med Hyg. 1982 Jul;31(4):830-6. doi: 10.4269/ajtmh.1982.31.830.

Abstract

Monoclonal antibodies produced against the four dengue virus serotypes identified four categories of reactions by immunofluorescence: flavivirus group reactive, dengue complex specific, dengue subcomplex specific (DEN-1, DEN-3), and dengue serotype specific. This is the first time that monospecific antibodies have been available for all of these unique antigenic determinants. Hybridoma cell lines producing dengue type-specific antibodies have been deposited in the Hybridoma Cell Bank of the American Type Culture Collection (Rockville, MD) for general distribution.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Viral / immunology*
  • Dengue Virus / immunology*
  • Flavivirus / immunology*
  • Fluorescent Antibody Technique
  • Humans
  • Hybridomas / immunology
  • Mice
  • Species Specificity

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral