Clustered arrangement of immunoglobulin lambda constant region genes in man

Nature. 1981 Dec 10;294(5841):536-40. doi: 10.1038/294536a0.

Abstract

The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome.

MeSH terms

  • Base Sequence
  • Biological Evolution
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • Genes
  • Genetic Linkage
  • Humans
  • Immunoglobulin Constant Regions / genetics*
  • Immunoglobulin Light Chains / genetics*
  • Immunoglobulin Variable Region / genetics
  • Immunoglobulin lambda-Chains / genetics*
  • Immunoglobulins / genetics*
  • Polymorphism, Genetic

Substances

  • Immunoglobulin Constant Regions
  • Immunoglobulin Light Chains
  • Immunoglobulin Variable Region
  • Immunoglobulin lambda-Chains
  • Immunoglobulins
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J00252
  • GENBANK/J00253
  • GENBANK/J00254