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Cell Tissue Res. 1978 Jan 31;186(3):535-40.

An autoradiographic study of satellite cell differentiation into regenerating myotubes following transplantation of muscles in young rats.

Abstract

Satellite cells were traced autoradiographically during the regeneration of skeletal muscle in young Sprague-Dawley rats. Approximately 31% of the satellite cells in uninjured muscles appeared labelled after three injections of tritiated thymidine; none of the myonuclei were labelled in the same muscles. Four to six days after transplanting the radioactive muscles to non-radioactive littermates, regenerating myotube nuclei in the host appeared labelled. Thus, this study confirms that satellite cells in young rats can differentiate into multinucleated myotubes following muscle injury.

PMID:
627031
DOI:
10.1007/bf00224941
[Indexed for MEDLINE]

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