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Nucleic Acids Res. 1981 Jun 11;9(11):2577-88.

Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a Gram-positive bacterium.

Abstract

The gene for the penicillinase from B. licheniformis has been cloned in a functional stat on a 1.5 kb DNA fragment and its nucleotide sequence has been determined. A sequence of 307 amino acid residues is infered for the penicillinase precursor. Of these 34 amino acids precede the sequence of the secreted form of the enzyme. This peptide extension shows the features of a signal for secretion and also provides the hydrophobic anchor for the membrane-bound form of the enzyme.

PMID:
6269055
PMCID:
PMC326873
DOI:
10.1093/nar/9.11.2577
[Indexed for MEDLINE]
Free PMC Article

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